RS 100329

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RS 100329 盐酸盐是 α1A-肾上腺素能受体的拮抗剂。

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.(In Vitro):In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2).

RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner.

RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions. Animal Model:Sprague Dawley rats (300-390 g) Dosage:0.01-0.1 mg/kg Administration:Intravenous injection Result:Caused a fall in baseline urethral pressure reaching a maximum of 23%.

RS-100329

Angiogenesis

Adrenergic Receptor

EGFR|c-Met

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1215654-26-4

462.89

C20H26ClF3N4O3

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (67.51 mM)

CC(C1=O)=CN=C(O)N1CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2.Cl

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(-20℃)

With Ice Pack

≥ 2 years